I do not feel the effect of ginseng

Dear JJ,

I originally did not want to write about the ginseng at all. But he can not be satisfied with his general understanding as a lifebuilder who heals everything and nothing. Ginseng and other adaptogens have specific, strong and long-lasting effects on the vascular, nervous and immune systems . These are not commonly known or used by our doctors and synthetic drug manufacturers. In medical journals, obviously rent articles (like Messina2006hsf ) appear that ginseng has "interactions" with drugs against thrombosis , diabetes , depression , etc. The aim of these articles is to conceal the fact that ginseng itself is a drug against thrombosis and diabetes. This, of course, is a breach of scientific and citation ethics that we are not used to here. I try to remedy this by providing a full view of the relevant professional literature.

And now to use ginseng ...

Ginseng is preparing properly. Be sure that if you measure the level of panaxosides in your blood or cerebrospinal fluid, you will see a slowly increasing concentration in the order of milligrams / liter. Be sure these panaxosides bind to the appropriate nuclear and non-nuclear receptors of the cells and act as they do.

The fact that you do not feel the effect can have several reasons:

1. Ginseng is used relatively briefly - effects come in three phases:

• Short-term effects occur within hours and days. They are caused by the direct interaction of panaxosides with non-nuclear receptors (receptors and enzymes in the membrane and the cytoplasm). This includes relaxing effect on blood vessels by allosteric boosting of NO synthase 3 , effect on non-nuclear receptors in the brain, or cell membrane stabilizing effect. These effects are directly proportional to the current panaxoside levels in the blood.
• Medium-term effects occur within days and weeks. These effects are due to panaxoside interactions with nuclear receptors and subsequent gene expression change. They come with a delay of several days with respect to the panaxoside blood curve because gene expression involves transcription of mRNA and translation of enzymes, which in humans lasts for many hours. It takes a few days to establish a new level of protein that is affected by these nuclear receptors. For example, the anti-inflammatory effect of ginseng works by limiting the expression of cycloxygenase via the nuclear receptor NF-κB, the effect on the glucocorticoid receptor, increased expression of NO synthase 3 in the blood vessels, etc. (Note: Panaxoside mixture in NO synthase 3 acts both as an allosteric and an increased expression of this enzyme.)
• Long-term effects occur over weeks and months. The human organism is in the constant process of rebuilding, and when some parameters of cell behavior change, it may take many months for it to be reflected in the re-engineering of tissue systems. Ginseng may begin to improve capillary growth some days after you start taking it, but it takes months to improve your blood vessel organs. Although ginseng suppresses inflammation of the joints , it takes a long time before the damaged tissue recovers. Although ginseng reassures microglia in the brain and macrophages on the internal walls of the vessels, it takes a long time to do so by reducing neuronal death and significantly slowing down atherosclerosis .

2. A dose of 3 slices per day may still not be high enough for subjective observation

Along with the effect on erection , the psychotropic effects are practically the only ones that you have the chance to notice for a short time with ginseng. In the case of ginseng, you can actually talk about happiness - they are adapogens, such as glans , who can not be subjectively acquainted with anything.

However, the dose of 3 slices may not be high enough to distinguish ginseng from natural mood swings and performance. You know, many people feel the doses of more than 3 slices too high, so I did not want to recommend larger doses. To tell the truth, as far as I am concerned, I do not feel anything like myself with my 90kg live weight at a dose of 3 slices. In a dose of 15 slices, the effects (for me) can not be overlooked, but I did not allow a high dose.

3. Ginseng is an adaptogen ...

The third reason is that ginseng as an adaptogen should not actually work or function in people beyond the burden. Its effect on the hypothalamic-pituitary (ie, stress) axis will manifest itself especially when you are under stress. After all, ginseng is not a panacea or a miracle. TCM physicians are pleased to say that even ginseng is not for everyone. Perhaps you are completely healthy, living a balanced life in a relatively clean environment, and you do not need ginseng. If this is the case, maintain a healthy lifestyle and save the time to the trumps.

Regards,
-boris-